Biotech Frontiers

Life-science and biotech investing is our focus in Biotech Frontiers… Some startups follow a clear, smooth path to success. Others skyrocket, then quickly fall back to Earth. But, generally speaking, as a sector, biotech stocks perform differently than tech stocks, “forever stocks,” and certainly the blue chips… Biotech veteran Erez Kalir heads up this advisory that publishes on the first Thursday of each month, with regular unscheduled updates as they are needed.

Issues & Updates


  • High Yield Precious Metals
    Today, in our penultimate installment of “12 Days,” analyst Ross Hendricks shares with readers some lessons learned from his experience overseeing Porter & Co.’s Trading Club… One takeaway: trading options is a smart way to generate income and boost overall returns, regardless of what the market does.
  • The Great Portfolio Experiment
    The performance of Porter’s Permanent Portfolio has been exceptional, performing exactly as it was designed to… and better that it was expected to. Great returns – with far lower volatility than the broader market. See what goes into it and why it works.
  • Don’t Fight City Hall
    Sometimes, the quality of an asset isn’t enough. In the energy markets, geography is destiny – and in 2025, we learned that even a billion barrels of oil can’t always beat a hostile local government.
  • Never Sell A Great Business
    Today, we take some lessons from two mistakes we made in our Complete Investor publication – either selling a great business too soon, or not buying it soon enough.


Special Reports

America’s Last Election